Маркер тубулярної дисфункції – ліпокалін, асоційований з желатиназою нейтрофілів
DOI:
https://doi.org/10.37987/1997-9894.2023.1(267).281396Ключові слова:
ліпокалін, хронічна хвороба нирок, біомаркери, білкиАнотація
У статті проведено огляд досліджень, присвячених вивченню прогностичної ефективності ліпокаліну, асоційованого із нейтрофільною желатиназою (NGAL). NGAL є предиктором гострого пошкодження нирок. Вміст NGAL у сечі є ефективнішим показником для діагностики гострого пошкодження нирок, порівняно з NGAL сироватки та плазми крові. Результати цього огляду доводять, що на прогностичну ефективність також впливають вік, стать (вища прогностична цінність у жінок, ніж у чоловіків), інфекція сечовивідних шляхів та порушення функції нирок (вища прогностична цінність у пацієнтів із хронічним захворюванням нирок) тощо.
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